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Inventi Impact: Biomedical Imaging

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  • Inventi:ebmi/64/14
    SPECIFIC CT 3D RENDERING OF THE TREATMENT ZONE AFTER IRREVERSIBLE ELECTROPORATION (IRE) IN A PIG LIVER MODEL: THE â??CHEBYSHEV CENTER CONCEPTâ? TO DEFINE THE MAXIMUM TREATABLE TUMOR SIZE
    30-Jun-2014 Research 2014 : July - September
    Dominik Vollherbst, Stefan Fritz, Sascha Zelzer, Miguel F Wachter, Maya B Wolf, Ulrike Stampfl,Daniel Gnutzmann, Nadine Bellemann, Anne Schmitz, Jurgen Knapp, Philippe L Pereira, Hans U Kauczor, JensWerner, Boris A Radeleff, Christof M Sommer

    Background: Size and shape of the treatment zone after Irreversible electroporation (IRE) can be difficult to depict\ndue to the use of multiple applicators with complex spatial configuration. Exact geometrical definition of the\ntreatment zone, however, is mandatory for acute treatment control since incomplete tumor coverage results in\nlimited oncological outcome. In this study, the ââ?¬Å?Chebyshev Center Conceptââ?¬Â was introduced for CT 3d rendering to\nassess size and position of the maximum treatable tumor at a specific safety margin.\nMethods: In seven pig livers, three different IRE protocols were applied to create treatment zones of different size\nand shape: Protocol 1 (n = 5 IREs), Protocol 2 (n = 5 IREs), and Protocol 3 (n = 5 IREs). Contrast-enhanced CT was\nused to assess the treatment zones. Technique A consisted of a semi-automated software prototype for CT 3d\nrendering with the ââ?¬Å?Chebyshev Center Conceptââ?¬Â implemented (the ââ?¬Å?Chebyshev Centerââ?¬Â is the center of the largest\ninscribed sphere within the treatment zone) with automated definition of parameters for size, shape and position.\nTechnique B consisted of standard CT 3d analysis with manual definition of the same parameters but position.\nResults: For Protocol 1 and 2, short diameter of the treatment zone and diameter of the largest inscribed sphere\nwithin the treatment zone were not significantly different between Technique A and B. For Protocol 3, short\ndiameter of the treatment zone and diameter of the largest inscribed sphere within the treatment zone were\nsignificantly smaller for Technique A compared with Technique B (41.1 Ã?± 13.1 mm versus 53.8 Ã?± 1.1 mm and 39.0 Ã?±\n8.4 mm versus 53.8 Ã?± 1.1 mm; p < 0.05 and p < 0.01). For Protocol 1, 2 and 3, sphericity of the treatment zone was\nsignificantly larger for Technique A compared with B.\nConclusions: Regarding size and shape of the treatment zone after IRE, CT 3d rendering with the ââ?¬Å?Chebyshev\nCenter Conceptââ?¬Â implemented provides significantly different results compared with standard CT 3d analysis. Since\nthe latter overestimates the size of the treatment zone, the ââ?¬Å?Chebyshev Center Conceptââ?¬Â could be used for a more\nobjective acute treatment control.

    How to Cite this Article
    CC Compliant Citation: Vollherbst et al.: Specific CT 3D rendering of the treatment zone after Irreversible Electroporation (IRE)\nin a pig liver model: the â??Chebyshev Center Conceptâ? to define the maximum treatable tumor size. BMC Medical Imaging 2014\n14:2, doi:10.1186/1471-2342-14-2.\n© 2014 Vollherbst et al.; licensee BioMed Central Ltd. \nThis is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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